Sundharraman Subramanian

Screening metatranscriptomes for ultrastable RNA secondary structures reveals hidden bacteriophages and novel capsid nanomaterials

Structures of two LarA-like nickel-pincer nucleotide cofactor-utilizing enzymes with a single catalytic histidine residue

The paper investigates two LarA-like enzymes lacking a catalytic histidine residue, solving their structures and revealing a novel octameric assembly and active site residues involved in carbohydrate metabolism.

Measuring the selective packaging of RNA molecules by viral coat proteins in cells

This study investigates how bacteriophage MS2 coat proteins selectively package viral RNA over host RNA, finding that selectivity arises from collective interactions rather than a single stem-loop.

Active E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments

The paper reports that E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments, revealing protein-protein interactions that support catalysis and mask transcriptional regulation.