Wen Jiang

This paper introduces ramped phase randomization to improve cryo-EM map comparison and data augmentation by reducing fine-scale detail while preserving low-frequency content and enhancing machine learning performance.

WebCalEM provides a browser-based tool for accurate pixel size calibration in cryo-EM, eliminating installation barriers and enabling routine use.

Helicon enables helical indexing and 3D reconstruction from a single 2D image using linear regression and regularization techniques.

The paper validates helical symmetry parameters in EMDB by identifying and correcting inconsistencies between parameters and density maps.

ESMAdam generates protein conformation ensembles efficiently using ESMFold and ADAM optimization, reducing computational time and adapting to diverse restraint conditions.

The paper reports that E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments, revealing protein-protein interactions that support catalysis and mask transcriptional regulation.

The paper reports the cryo-EM structures of Vibrio phage XM1, revealing its contractile tail and baseplate components, and proposes mechanisms of assembly and infection.

The paper determines that tau and TMEM106B filaments from gray and white matter in MSTD have identical folds.

The paper determines the cryo-EM structure of E. coli σ70 RNAP and promoter DNA complex, revealing a role of σNCR in open complex formation.

This paper demonstrates a 2.6 Å resolution structure solved using antibody-based affinity cryo-EM with a low-concentration Tulane virus sample, showing its potential for high-resolution structural studies.