Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease
Aditya Barve, Adam B. Cornwell, Pramika Sriram, Oleg V. Kopyov, Preeti Dabas, Emilia Kooienga, Zakiya Kelley, James D. Johnson, Jacquelyn Myers, Esther A. Obeng, Guolian Kang, Yunusa Olufadi, Terri L. Cain, Lindsay Jones Talbot, David D. Spence, , Shannon McKinney‐Freeman
This study shows senolytics like ABT-263 restore bone marrow function in sickle cell disease by reversing HSC dysfunction and senescence in mice.
bioRxiv · Feb 8, 2025 · PreprintCell Biology