ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites
Vera Filipa Monteiro-Cardoso, Valentin Guyard, Jennica Träger, Cécile Sauvanet, Helin Elhan, Mehdi Zouiouich, Naïma El Khallouki, Yoshiki Yamaryo‐Botté, David C. Tareste, Cyrille Y. Botté, Abdou Rachid Thiam, Francesca Giordano
This study identifies ORP5 as a key regulator of phosphatidic acid partitioning between triacylglycerol and cardiolipin synthesis at MAM-LD junctions, showing its role in balancing lipid metabolism and mitochondrial health.
bioRxiv · Nov 6, 2025 · PreprintCell Biology