Timothy James Kendall

DUCK-Net: Automated deep learning segmentation of Ductular Reaction in murine liver injury captures multicellular niche dynamics from H&E morphology

This paper introduces DUCK-Net, a deep learning model for automated segmentation of Ductular Reactions in murine liver injury, showing high accuracy and correlation with spatial transcriptomic data.

Mapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver disease

The paper identifies novel fibrosis-associated endothelial cells in early-stage liver disease through integrated analysis of imaging, proteomic, and transcriptomic data.

Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis.

This study shows that regulatory T cells (Tregs) influence bile duct regeneration during cholangitis, and their stability is critical for reducing fibrosis and inflammation.

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease

Epithelial state-transitions permit inflammation-induced tumorigenesis.

This study identifies epithelial state transitions driven by inflammation that promote tumorigenesis, showing that targeting NOTCH signaling can prevent pre-neoplastic to neoplastic transition.

Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunction

The paper combines stem cell models and computational predictions to identify flavin cofactors as therapeutic targets for metabolic liver dysfunction.