Harshal H. Nandurkar

This paper shows that targeting CD39 on endothelial cells prevents toxin-induced pulmonary hypertension in mice by multiple mechanisms including adenosine signaling and reducing inflammation.

This paper develops an endothelial-targeted CD39 therapy for ischaemic stroke, showing reduced infarct size and improved BBB integrity when administered 3 hours post-ischaemia.

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.