Endothelial-targeted CD39 prevents Toxin-induced Pulmonary Hypertension Mice.
Abbey Willcox, Ioanna Savvidou, Natasha Ting Lee, Carly Selan, Ilaria Calvello, Simon Christopher Robson, Viktoria Bongcaron, Aidan P. G. Walsh, Yuyang Song, Xiaowei Wang, Trevor Williams, Karlheinz Peter, Harshal H. Nandurkar, Maithili Sashindranath
This paper shows that targeting CD39 on endothelial cells prevents toxin-induced pulmonary hypertension in mice by multiple mechanisms including adenosine signaling and reducing inflammation.
bioRxiv · Nov 5, 2025 · PreprintPhysiology