This study shows that Ritlecitinib reduces neointima formation and enhances endothelial recovery after vascular injury by modulating JAK3 signaling and VEGF-A/TSP-1 pathways.

bioRxiv · Sep 23, 2025 · PreprintPathology

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

Shujuan Zhao, Kedous Y. Mekbib, Martijn A. van der Ent, Garrett Allington, Andrew E. Prendergast, Jocelyn E. Chau, Hannah Louise Smith, John P. Shohfi, Jack Ocken, Daniel Durán, Charuta Gavankar Furey, Hao Thi Le, Phan Q. Duy, Benjamin C. Reeves, Junhui Zhang, , Kristopher Thomas Kahle

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

bioRxiv · Mar 18, 2023 · PreprintGenomics

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling

Rui Tang, Yung-Chun Wang, Xiaohan Mei, Ning Shi, Chenming Sun, Ran Ran, Gui Zhang, Wenjing Li, Kevin F. Staveley-O’Carroll, Guangfu Li, Shi‐You Chen

This study identifies GAS5 as a regulator of TGF-β-induced fibroblast activation by inhibiting Smad3 signaling, showing therapeutic potential for fibrotic diseases.

American Journal of Physiology-Cell Physiology · May 6, 2020Peer-reviewedMolecular Biology