Rui Tang

CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seeding

This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.

Quantitative dissection of the metastatic cascade at single colony resolution

This paper introduces MOBA-seq, a platform to map genetic regulators of metastasis at single-colony resolution, identifying tissue-specific suppressors and universal essential genes.

Aging represses lung tumorigenesis and alters tumor suppression

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling

This study identifies GAS5 as a regulator of TGF-β-induced fibroblast activation by inhibiting Smad3 signaling, showing therapeutic potential for fibrotic diseases.