Richard A. Moffitt

The paper integrates MetScore with classical-basal subtype to better explain PDAC metastasis, prognosis, treatment response, and tumor microenvironment than a single-axis model.

This study investigates the differential roles of HNF4α isoforms P1 and P2 in PDAC growth and differentiation, finding P2 supports growth better than P1.

This paper introduces SSCD, a method to improve differential expression and survival analyses by deconvolving tumor samples into their component tissues on a per-sample basis.

The paper identifies a unique microglial subset at the tumor-stroma interface in gliomas that correlates with poor prognosis and suggests it as a therapeutic target.

DECODER deconvolves tumor samples to estimate compartment weights, showing clinical relevance in pancreatic cancer and applicability to other data types.