Nikolaos Nikolaou

This study generates iPSC-derived hepatocytes from A1ATD donors and shows they recapitulate disease features and respond to drug treatments, offering a model for drug screening.

This paper develops optimised human iPSC-derived hepatocytes (Opti-HEP) with improved liver function for metabolic disease modelling and toxicity studies, showing comparable functionality to primary human hepatocytes.

This study examines the differential expression and activity of three AKR1D1 splice variants in human tissues and cells, showing that AKR1D1-002 is the main functional variant involved in steroid hormone metabolism.