Author
University of CambridgeORCID 0000-0002-2353-8247Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Carlos Gil, Vanesa Papastavrou, Gemma Gatti…·Nikolaos Nikolaou
This study generates iPSC-derived hepatocytes from A1ATD donors and shows they recapitulate disease features and respond to drug treatments, offering a model for drug screening.
Magdalena Łukasiak, Gemma Gatti, Samuel Chung…·Nikolaos Nikolaou
This paper develops optimised human iPSC-derived hepatocytes (Opti-HEP) with improved liver function for metabolic disease modelling and toxicity studies, showing comparable functionality to primary human hepatocytes.
Elangovan Boobalan, A. Thompson, Ramakrishna P. Alur…·Brian P. Brooks
The paper shows that Zfp503 is essential for RPE differentiation and optic fissure closure, with loss of function leading to uveal coloboma and altered gene expression in developing mouse eyes.