Author

Gabriella L. Gentile

University of North Carolina at Chapel HillORCID 0000-0002-8809-0260Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adriana Le VaniD· 1 shared Ann E. JerseiD· 1 shared Bryan B. GuzmániD· 1 shared Daniel DomingueziD· 1 shared Robert A. NicholasiD· 1 shared Tatum D. MortimeriD· 1 shared Yonatan H. GradiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Adriana Le VanORCID

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1 paper

Recent·Most cited

The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae

Gabriella L. Gentile, Bryan B. Guzmán, Adriana Le Van, Ann E. Jerse, Yonatan H. Grad, Daniel Dominguez, Tatum D. Mortimer, Robert A. Nicholas

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

bioRxiv · Jun 27, 2025 · PreprintMicrobiology