Yonatan H. Grad

This paper introduces BASS-GWAS, a Bayesian method for efficient microbial GWAS, identifying causal loci with fewer phenotyped isolates than random sampling.

This study shows that gyrA variants from ciprofloxacin resistance increase zoliflodacin resistance and fitness cost of the gyrB D429N mutation in N. gonorrhoeae.

The paper evaluates the in vitro activity of pairwise antibiotic combinations against Neisseria gonorrhoeae, finding no evidence of antagonism.

This study identifies aerocavin as a potent and specific antibiotic against Neisseria, showing it inhibits bacterial RNA polymerase and has low resistance evolution rates in N. gonorrhoeae.

The paper uses long-read sequencing to analyze opa gene diversity in Neisseria gonorrhoeae genomes, revealing high variability and rapid evolution of these genes.

This study shows that the gyrBD429N mutation in Neisseria gonorrhoeae confers cross-resistance to gepotidacin and has variable fitness effects across strains.

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

This study shows that axial asymmetry in Neisseria gonorrhoeae guides orthogonal division planes, maintaining diplococcal morphology through ParB segregation and MinCDE system function.

This study quantifies how antibiotic use and genetic resistance determinants affect bacterial lineage dynamics using a Bayesian model and Neisseria gonorrhoeae isolates.

This paper introduces a community-driven genomic resource for Neisseria gonorrhoeae that predicts antimicrobial resistance and supports public health surveillance.

The paper evaluates targeted sampling strategies for detecting novel antibiotic resistance variants in Neisseria gonorrhoeae, finding that pathogen-based approaches are more efficient than patient-based ones.

The paper analyzes mumps virus circulation in the US using genomic data to show multiple co-circulating lineages and transmission patterns, but finds no evidence of vaccine escape variants.

This paper introduces a method to rapidly infer antibiotic resistance and susceptibility from bacterial genomes using genomic neighbor typing, achieving high sensitivity and specificity within minutes to hours.

This study traces the evolutionary divergence of Neisseria gonorrhoeae by analyzing global isolates, linking antimicrobial use to the emergence of two distinct lineages with different resistance strategies.

The paper presents a Bayesian model to estimate bacterial acquisition and clearance rates by accounting for within-host genetic variation and sampling intervals, validated using simulations and applied to MRSA isolates.