Jennifer L. Imm

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.

This study identifies neuron-specific DNA methylation changes in Parkinson's disease prefrontal cortex, revealing hypermethylation at seven novel loci and highlighting the importance of cell-type-specific analysis.

CEAM is a tool for analyzing DNA methylation data to identify cell type-specific patterns, validated on neurodegenerative disease datasets.

The paper develops a novel epigenetic clock for fetal brain development to predict prenatal age in iPSCs and derived neurons, showing they remain epigenetically fetal despite differentiation.