Leonard C. Steg

Paternal diet shapes paternal and maternal transcriptomes in the early embryo through parallel sperm-associated mechanisms

The paper shows that paternal diet affects both paternal and maternal transcriptomes in early embryos through distinct sperm-related mechanisms.

Circulating extracellular vesicles can transport stress signals to the male germline

The paper shows that stress-induced changes in extracellular vesicles from mice can alter sperm and embryo transcriptomes, leading to metabolic issues in offspring.

NanoTag - an IgG-free method for mapping DNA-protein interactions

NanoTag is an IgG-free method for mapping DNA-protein interactions using a nanobody-Tn5 transposase fusion, showing high correlation with CUT&Tag data in mouse embryonic stem cells.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

The paper develops a novel epigenetic clock for fetal brain development to predict prenatal age in iPSCs and derived neurons, showing they remain epigenetically fetal despite differentiation.

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

The paper examines chromatin remodeling and gene expression dynamics in mouse spermatogonial cells across postnatal development using RNA-seq and ATAC-seq.