Author
University of ExeterORCID 0000-0001-6423-9983Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Katherine Fodder, Megha N. Murthy, Joshua Harvey, Ehsan Pishva, Katie Lunnon, Towfique Raj, Kurt W. Farrell, Rohan de Silva, Jack Humphrey, Conceição Bettencourt
The paper identifies shared genetic and epigenetic mechanisms at the MOBP locus linking ALS and PSP, with distinct patterns from MSA.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience
Giulia Pegoraro, Lachlan Ford MacBean, Adam R. Smith, Darren M. Soanes, Rebecca G. Smith, Jennifer L. Imm, Joshua Harvey, Morteza P Kouhsar, Valentin Laroche, Luke Stephen Weymouth, Isabel Castanho, Winston Hide, Laura Palmer, Debra J. Lett, Andrew Robinson, , Katie Lunnon
This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.
Neurobiology of Aging · Jun 26, 2026Peer-reviewedNeuroscience
Valentin Laroche, Rachel Cavill, Morteza P Kouhsar, Joshua Müller, Rick A. Reijnders, Joshua Harvey, Adam R. Smith, Jennifer L. Imm, Jarno Koetsier, Luke Stephen Weymouth, Lachlan Ford MacBean, Giulia Pegoraro, Lars Eijssen, Byron Creese, Günter Kenis, , Ehsan Pishva
This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.
Acta Neuropathologica · Feb 24, 2026Peer-reviewedGenomics
Anthony Klokkaris, Eilis J. Hannon, Joe Burrage, Barry A. Chioza, Adam R. Smith, Joshua Harvey, Alice Franklin, Luke Stephen Weymouth, Jennifer L. Imm, Katie Lunnon, Emma Louise Dempster, Jonathan S. Mill, Anna Migdalska‐Richards
This study identifies neuron-specific DNA methylation changes in Parkinson's disease prefrontal cortex, revealing hypermethylation at seven novel loci and highlighting the importance of cell-type-specific analysis.
medRxiv · Feb 9, 2026 · PreprintGenetic & Genomic Medicine
Joshua Müller, Valentin Laroche, Jennifer L. Imm, Luke Stephen Weymouth, Joshua Harvey, Rick A. Reijnders, Adam R. Smith, Daniël van den Hove, Katie Lunnon, Rachel Cavill, Ehsan Pishva
CEAM is a tool for analyzing DNA methylation data to identify cell type-specific patterns, validated on neurodegenerative disease datasets.
Epigenetics · Dec 22, 2025Peer-reviewedGenomics
Joshua Harvey, Adam R. Smith, Luke Stephen Weymouth, Rebecca G. Smith, Isabel Castanho, Leon Hubbard, Byron Creese, Catherine Bresner, Nigel M. Williams, Ehsan Pishva, Katie Lunnon
The paper identifies a DNA methylation module in the substantia nigra associated with depressive symptoms in Parkinson's disease.
npj Parkinson s Disease · Mar 2, 2025Peer-reviewedNeuroscience
Jarno Koetsier, Rachel Cavill, Rick A. Reijnders, Joshua Harvey, Jan Homann, Morteza P Kouhsar, Kay Deckers, Sebastian Köhler, Lars Eijssen, Daniël van den Hove, Ilja Demuth, Sandra Düzel, Alzheimer’s Disease Neuroimaging Initiative, Rebecca G. Smith, Adam R. Smith, , Ehsan Pishva
The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.
Alzheimer s & Dementia · Aug 28, 2024Peer-reviewedGenetic & Genomic Medicine
Terri‐Leigh Stephen, Francesco Tamagnini, Judith Piegsa, Katherine Sung, Joshua Harvey, Alice Oliver‐Evans, Tracey K. Murray, Zeshan Ahmed, Michael L. Hutton, Andrew D. Randall, Michael J. O’Neill, Johanna Jackson
The paper examines how Aβ plaques develop and affect synaptic density and turnover in a mouse model of Alzheimer's disease, finding an imbalance in pre- and post-synaptic responses.
Scientific Reports · Oct 16, 2019Peer-reviewedNeuroscience
Isabel Castanho, Tracey K. Murray, Eilis J. Hannon, Aaron R. Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Andrew D. Randall, Karen Moore, Paul O’Neill, Katie Lunnon, David Andrew Collier, Zeshan Ahmed, Michael J. O’Neil, Jonathan S. Mill
This study identifies transcriptional changes in tau and amyloid mouse models, revealing gene expression patterns linked to AD pathology and immune response.
bioRxiv · Feb 13, 2019 · PreprintGenomics