Aurélie Teissandier

Spatio-temporal X-linked gene reactivation and site-specific retention of epigenetic silencing in the in vivo germline.

The paper maps X-linked gene reactivation and epigenetic silencing in developing PGCs, showing partial resistance to reactivation and enrichment of repressive marks.

DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

This study shows that DNA methylation is critical for restricting neural differentiation but not germline fate in ESCs, with TKO ESCs capable of germline specification.

Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.

MET functions in tumour progression and therapy resistance are repressed by intronic polyadenylation

The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.

Assessing the influence of distinct IVF culture media on human pre-implantation development using single-embryo transcriptomics

This study uses single-embryo transcriptomics to assess how different IVF culture media affect gene expression in human preimplantation embryos, showing medium-specific effects that diminish by the blastocyst stage.

DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis

This study shows that DNMT3A-dependent DNA methylation is essential for spermatogonial stem cells to commit to differentiation and spermatogenesis.

The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

This study shows that the imprinted Zdbf2 gene is critical for neonatal growth and feeding adaptation in mice, with loss of function leading to poor survival and reduced body weight.

Dynamic enhancer partitioning instructs activation of a growth regulator during exit from naïve pluripotency

The paper shows that CTCF-mediated enhancer partitioning controls the promoter switch of Zdbf2 during exit from naïve pluripotency, independent of polycomb and DNA methylation.