MET functions in tumour progression and therapy resistance are repressed by intronic polyadenylation
Galina Boldina, Maricarmen Vallejos, Delphine Allard, Mandy Cadix, Céline M. Labbé, Sophie Vacher, Oskar Hemmingsson, Pierre Gestraud, Aurélie Teissandier, Sylvain Martineau, Didier Auboeuf, Fabrice André, Maud T Kamal, Nicolas Servant, Ivan Bièche, , Stéphan Vagner
The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.
bioRxiv · Aug 9, 2023 · PreprintMolecular Biology