Itallia V. Pacentine

PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade

This study identifies stem-monocytic AML as a distinct subtype resistant to venetoclax and shows that PU.1 inhibition synergizes with BCL2 blockade to enhance therapeutic response.

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

Complex carbohydrates catabolism capacity of bladder microbiota inhabiting healthy and overactive female bladders

This study investigates urinary free oligosaccharides and microbial gene capacity for glycan digestion in women with and without overactive bladder syndrome.

The lhfpl5 ohnologs lhfpl5a and lhfpl5b are required for mechanotransduction in distinct populations of sensory hair cells in zebrafish.

This paper investigates the roles of lhfpl5a and lhfpl5b in mechanotransduction in zebrafish hair cells, showing distinct expression patterns and functional contributions to sensory systems.

Putative pore-forming subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize to the site of mechanotransduction in zebrafish sensory hair cells

The paper shows that Tmie is required for the localization and stabilization of Tmc1/2b subunits at the mechanotransduction site in zebrafish hair cells, linking Tmie function to channel activity.