Julia E. Maxson

PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade

This study identifies stem-monocytic AML as a distinct subtype resistant to venetoclax and shows that PU.1 inhibition synergizes with BCL2 blockade to enhance therapeutic response.

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia

This study identifies MYST acetyltransferases as therapeutic targets in SETBP1-mutant leukemia, showing that MYST inhibitors reduce target gene expression and improve survival in mouse models.

CITE-Viz: Replicating the Interactive Flow Cytometry Workflow in CITE-Seq

CITE-Viz is a visualization tool for CITE-Seq data that replicates flow cytometry gating workflows to enable cell cluster classification and multi-omic analysis.

GoPeaks: Histone Modification Peak Calling for CUT&Tag

GoPeaks is a peak calling method for CUT&Tag data that improves sensitivity in detecting H3K27Ac peaks compared to standard algorithms.