Author

Wai Lim Ku

National Institutes of HealthORCID 0000-0002-8859-6771Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Keji ZhaoiD· 4 shared Xin CheniD· 2 shared Annabelle Song· 1 shared Benjamin C. CarteriD· 1 shared Chinmayi Chandrasekhara· 1 shared Emily Naylor· 1 shared Gangqing HuiD· 1 shared Jee Youn Kang· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersDevelopmental Biology

Keji ZhaoORCID

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4 papers

Recent·Most cited

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy

Na Liu, Junji Xu, Wai Lim Ku, Weiwei Chen, Yaqiang Cao, Rida Kazmi, Wenwen Jin, Thierry Gauthier, Shunqun Luo, Song Shen, Liliana Catherine Patiño, Yun-Ji Lim, Valentina Ottaviani, Emily Naylor, Keji Zhao, WanJun Chen

This paper shows that anti-CTLA-4 antibodies destabilize intratumor Tregs via TGF-β signaling, enhancing anti-tumor immunity and immunotherapy.

bioRxiv · Aug 1, 2026 · PreprintImmunology

The Drosophila histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation

Velinda Vidaurre, Annabelle Song, Taibo Li, Wai Lim Ku, Keji Zhao, Jiang X. Qian, Xin Chen

This study shows that the Drosophila SET1 histone methyltransferase regulates male germline stem cell maintenance and differentiation by coordinating JAK-STAT and BMP signaling pathways.

Development · Jul 15, 2024Peer-reviewedDevelopmental Biology

Roles of the distinct N-terminal amino acid between H3 and H3.3 in Drosophila male germline stem cell lineage

Chinmayi Chandrasekhara, Rajesh Ranjan, Jennifer A. Urban, Wai Lim Ku, Jonathan C. Snedeker, Keji Zhao, Xin Chen

This study shows that the N-terminal amino acid difference between H3 and H3.3 in Drosophila male germline stem cells affects their inheritance patterns and function in stem cell maintenance and differentiation.

bioRxiv · Sep 3, 2022 · PreprintDevelopmental Biology

Mapping Histone Modifications in Low Cell Number and Single Cells Using Antibody-guided Chromatin Tagmentation (ACT-seq)

Benjamin C. Carter, Wai Lim Ku, Jee Youn Kang, Gangqing Hu, Jonathan Perrie, Qingsong Tang, Keji Zhao

ACT-seq is a new method for mapping histone modifications and chromatin proteins in single cells, using antibody-guided chromatin tagmentation to streamline the process.

Nature Communications · Aug 20, 2019Peer-reviewedGenomics