Cancer BiologybioRxivPreprint
ZNF180 modulates tumor intrinsic immunotherapy resistance in melanoma through driving plasticity
Won‐Min Song, Sree Karani Kondapuram, Xianxiao Zhou…·Praveen Kumar Agrawal
This study identifies ZNF180 as a driver of immunotherapy resistance in melanoma by promoting tumor plasticity and immune suppression through mechanisms involving MHC-I loss, CD155 expression, and CD4 T-cell exclusion.
DOI 10.1101/2025.09.16.676573