Wenxue Li

aaRSID, an engineered pyrrolysyl-tRNA synthetase platform for multi-probe proximity proteomics

The paper introduces aaRSID, an engineered pyrrolysyl-tRNA synthetase for proximity labeling, improving upon existing tools by reducing background and enabling multiplexed proteomics.

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosis

This study identifies Fibulin-2 as a matrix cue that transduces fibrotic ECM remodeling into mitochondrial metabolic reprogramming in kidney fibrosis.

Acute Degradation of Pumilio Proteins Uncovers a Biphasic Post-transcriptional Regulatory Hierarchy Controlling Embryonic Stem Cell Fate Decisions

This study shows that acute Pum1/2 degradation in mouse ESCs reveals a biphasic post-transcriptional regulatory network affecting pluripotency and lineage decisions.

Stiffness sensing fuels matrix-driven metabolic reboot for kidney repair and regeneration

This study identifies Mfap2 as a key ECM component that regulates kidney repair by linking mechanical cues to metabolic reprogramming through Esr2-mediated transcriptional control.

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.