Sarah A. Slavoff

This study uses HaloPROTAC-mediated SOX10 degradation in melanoma cells to identify novel target genes and reveal SOX10's role in drug resistance and metastasis.

This study identifies GndA, a microprotein in Escherichia coli, which promotes cell growth during heat shock independently of its overlapping 6PGD protein.

The paper introduces aaRSID, an engineered pyrrolysyl-tRNA synthetase for proximity labeling, improving upon existing tools by reducing background and enabling multiplexed proteomics.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

The paper assesses MS-based identifications of unannotated human microproteins, finding large variation in reported proteins and PSM quality across studies.

The paper shows that non-coding alternative transcripts enable translation of iORFs, and that iORF-encoded proteins have distinct functions from their overlapping annotated proteins.

The paper identifies nascent alternative proteins in human cells using chemoproteomics and shows one represses ribosome biogenesis.

The paper identifies alt-RPL36 as a novel regulator of PI3K-AKT-mTOR signaling through interaction with TMEM24, showing its role in modulating PI(4,5)P2 levels and cell size.