Marta Giménez-Alejandre

This study identifies C1q from C1q+ tumor-associated myeloid cells as a key immunosuppressive factor in glioblastoma that impairs T-cell engagers and CAR T-cell efficacy, induced by LIF and glucocorticoids.

This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.

The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.