Martyna Lukoseviciute

Reconstitution of the Spinal Cord Injury Microenvironment in Adult Neural Stem Cell-Derived Organoids

This paper introduces neuroids, a modular organoid system that mimics the adult spinal cord injury microenvironment to study NSC differentiation and gliogenic bias.

Segregation of neural crest specific lineage trajectories from a heterogeneous neural plate border territory only emerges at neurulation

The paper uses single-cell RNA-seq to show that neural crest lineage segregation from the neural plate border occurs at early neurulation, not gastrulation.

Neuromesodermal progenitor origin of trunk neural crest in vivo

The paper shows that trunk neural crest in zebrafish originates from pro-neural neuromesodermal progenitors, revealing a shared origin with these progenitors and explaining their pro-neural bias.

From pioneer to repressor: Bimodal foxd3 activity dynamically remodels neural crest regulatory landscape in vivo

This study shows foxd3 acts as a pioneer factor and then switches to a repressor in neural crest cells, dynamically remodeling chromatin structure to control stemness and cell fate.