Daria Gavriouchkina

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

This paper develops a scalable human neuronal model of 4R tauopathy with endogenous seed-competent tau for drug discovery.

Parental care is a genetic capacitor

This study shows parental care in burying beetles acts as a genetic capacitor, storing and releasing genetic variation in offspring body size through molecular mechanisms involving chaperones and chromatin state.

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

Spatially Resolved Microglial Expression Around Aβ Plaques in Human Alzheimers Disease Tissue

The paper identifies gene expression changes in microglia around Aβ plaques in human Alzheimer's disease tissue and finds cross-species concordance with mouse data.

Transcriptomic analysis of repeat expansion-ataxias uncovers distinct non-neuronal cell type-specific signatures of disease across the human brain

This study uses bulk and single nuclear RNA-sequencing to analyze transcriptomic changes in repeat expansion ataxias, revealing distinct non-neuronal cell type-specific disease signatures across the human brain.

The hagfish genome and the evolution of vertebrates

This study analyzes the hagfish genome to understand vertebrate evolution, identifying ancient genome duplications and their functional roles in vertebrate innovations.

A genome-wide assessment of the ancestral neural crest gene regulatory network

This study analyzes the neural crest gene regulatory network in sea lampreys to identify conserved and unique elements across vertebrates.

Reconstruction of the global neural crest gene regulatory network in vivo

The paper reconstructs the global neural crest gene regulatory network in vivo using epigenomic and single-cell transcriptome data combined with genome engineering.

From pioneer to repressor: Bimodal foxd3 activity dynamically remodels neural crest regulatory landscape in vivo

This study shows foxd3 acts as a pioneer factor and then switches to a repressor in neural crest cells, dynamically remodeling chromatin structure to control stemness and cell fate.

Generation Of A Double Binary Transgenic Zebrafish Model To Study Myeloid Gene Regulation In Response To Melanocyte Transformation

The paper develops a double binary zebrafish model to study myeloid gene regulation during melanocyte transformation and melanoma initiation.