Sarah Mayes

RegVelo integrates gene regulatory networks with dynamic modeling to predict cellular changes and perturbations, showing improved performance in cell cycle, hematopoiesis, and pancreatic development datasets.

This paper introduces a method to modulate CRISPR activity in response to RNA detection using engineered guide RNAs, demonstrating functionality in mammalian cells and zebrafish embryos.

The paper identifies enhancers regulating Chd7 expression in neural crest cells and validates their function in chick embryos, revealing tissue-specific regulation of a chromatin remodeller.

The paper identifies gene regulatory circuits controlling cranial neural crest migration and plasticity using multi-omics and computational methods.

The paper adapts the Ac/Ds transposition system to enable CRISPR/dCas9 interference for studying non-coding RNAs and enhancers in zebrafish without altering genetic sequences.

The paper shows that trunk neural crest in zebrafish originates from pro-neural neuromesodermal progenitors, revealing a shared origin with these progenitors and explaining their pro-neural bias.