Author

Upeka Senanayake

University of OxfordORCID 0000-0003-2130-7709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Organism:multiple species· 1

Frequent Co-Authors

Tatjana Sauka‐SpengleriD· 4 shared Ruth M. WilliamsiD· 3 shared Daria GavriouchkinaiD· 2 shared Emmanouela RepapiiD· 2 shared Vanessa Chong-MorrisoniD· 2 shared Adam J. MeadiD· 1 shared Ahmed A. AhmediD· 1 shared Daniel WellsiD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersDevelopmental Biology

Tatjana Sauka‐SpenglerORCID

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4 papers

Recent·Most cited

Developmental BiologyBiology OpenPeer-reviewedJun 15, 2023

Re-purposing Ac/Ds transgenic system for CRISPR/dCas9 modulation of enhancers and non-coding RNAs in zebrafish

Vanessa Chong-Morrison, Sarah Mayes, Filipa Costa Simões…·Tatjana Sauka‐Spengler

The paper adapts the Ac/Ds transposition system to enable CRISPR/dCas9 interference for studying non-coding RNAs and enhancers in zebrafish without altering genetic sequences.

8 citations

zebrafishexperimental assay

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Developmental BiologyDevelopmental CellPeer-reviewedOct 1, 2019

Reconstruction of the global neural crest gene regulatory network in vivo

Ruth M. Williams, Ivan Candido-Ferreira, Emmanouela Repapi…·Tatjana Sauka‐Spengler

The paper reconstructs the global neural crest gene regulatory network in vivo using epigenomic and single-cell transcriptome data combined with genome engineering.

144 citationstop 2%

mousescRNA-seq

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Developmental BiologyDevelopmental CellPeer-reviewedDec 1, 2018

From pioneer to repressor: Bimodal foxd3 activity dynamically remodels neural crest regulatory landscape in vivo

Martyna Lukoseviciute, Daria Gavriouchkina, Ruth M. Williams…·Tatjana Sauka‐Spengler

This study shows foxd3 acts as a pioneer factor and then switches to a repressor in neural crest cells, dynamically remodeling chromatin structure to control stemness and cell fate.

116 citationstop 3%

mousescRNA-seq

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Developmental BiologyDevelopmentPeer-reviewedJan 31, 2018

Genome And Epigenome Engineering CRISPR Toolkit For Probing In Vivo cis-Regulatory Interactions In The Chicken Embryo

Ruth M Williams, Upeka Senanayake, Mara Artibani…·Tatjana Sauka‐Spengler

The paper develops a CRISPR-based toolkit for genome and epigenome engineering in chicken embryos to study gene regulatory interactions during neural crest development.

82 citations

multiple speciesexperimental assay

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