This paper introduces a rapid, portable assay to measure neutralizing antibodies against SARS-CoV-2 variants using gold nanoparticles and optical extinction detection.

Biosensors and Bioelectronics · Nov 6, 2024Peer-reviewedImmunology

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

Jason Z. Zhang, Andy Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca S. Treger, Alfredo Quijano‐Rubio, Minh Nguyet Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, , David A. Baker

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.

Nature Biotechnology · Apr 28, 2022Peer-reviewedMolecular Biology

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

Andrew C. Hunt, James Brett Case, Young‐Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Andy Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, , David A. Baker

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

Science Translational Medicine · Apr 12, 2022Peer-reviewedSynthetic Biology