Wei Yang

Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists

This study uses target-conditioned diffusion to design high-affinity TNFR superfamily antagonists and agonists with switchable specificity.

Induction and in silico staging of human gastruloids with neural tube, segmented somites & advanced cell types

This study induces human gastruloids with embryo-like structures using retinoic acid and shows they match E9.5 mouse embryos in developmental stage through single-cell RNA-seq and computational staging.

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.

Submodular sketches of single-cell RNA-seq measurements

The paper demonstrates using submodular optimization to create efficient, high-quality sketches of single-cell RNA-seq data.