Author

Michelle DeWitt

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

David A. BakeriD· 3 shared Alfredo Quijano‐RubioiD· 2 shared K. Christopher GarcíaiD· 2 shared Kevin M. JudeiD· 2 shared Lance J. StewartiD· 2 shared Lauren P. CarteriD· 2 shared A G MurrayiD· 1 shared Aerin YangiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

David A. BakerORCID

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Author profile →

3 papers

Recent·Most cited

Potent antitumor activity of a designed interleukin-21 mimic

Jung-Ho Chun, Birkley S. Lim, Suyasha Roy, Michael J. Walsh, Gita C. Abhiraman, Kevin Zhangxu, Tavus Atajanova, Or‐Yam Revach, Elisa C. Clark, Peng Li, Claire A. Palin, Asheema Khanna, Samantha J Tower, Rakeeb Kureshi, Megan T. Hoffman, , David A. Baker

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

Science Immunology · Sep 26, 2025Peer-reviewedBiochemistry

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

Jason Z. Zhang, Andy Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca S. Treger, Alfredo Quijano‐Rubio, Minh Nguyet Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, , David A. Baker

The paper introduces a thermodynamically coupled biosensor to rapidly detect neutralizing antibodies against SARS-CoV-2 strains in serum samples.

Nature Biotechnology · Apr 28, 2022Peer-reviewedMolecular Biology

Robust de novo design of protein binding proteins from target structural information alone

Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel R. Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, , David A. Baker

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.

bioRxiv · Sep 4, 2021 · PreprintSynthetic Biology