Martina Schuschnig

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation

The paper identifies a lipid transfer-dependent feedback loop that activates ATG9A compartments during autophagy initiation by enhancing ATG2A-mediated lipid transfer and ATG8 lipidation.

Activation of the bridge-like lipid transfer protein Atg2 by Atg1-mediated phosphorylation

This study identifies Atg1-mediated phosphorylation of Atg2 as a mechanism to activate lipid transfer during autophagosome biogenesis.

TAX1BP1 recruitment reactivates autophagy of Tau aggregates through ULK1 and TBK1

This study shows that TAX1BP1 recruitment to Tau aggregates reactivates autophagy through ULK1 and TBK1, enabling their clearance in neurodegenerative diseases.

Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

Mechanism of TAX1BP1 recruitment in aggrephagy to switch from cargo collection to sequestration

The paper investigates how TAX1BP1 recruits the autophagy machinery to switch from cargo collection to sequestration in aggrephagy.