Jan F. M. Stuke

The paper evaluates how specific PTMs affect tau protein aggregation using HCG and atomistic MD simulations, showing their impact on structural properties and aggregation behavior.

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

The paper uses AlphaFold to model polyubiquitin complexes and covalently linked proteins by introducing correlated mutations and covalent linkers to improve structural predictions.

The paper presents a fragment-based approach to improve LIR prediction using AlphaFold2, showing that fragment length and phosphomimetic mutations affect interaction predictions.