Author

Jikai Deng

Wuhan UniversityORCID 0000-0002-4429-8406Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Li ZhouiD· 2 shared Xiaoya Huang· 2 shared Hongyun Wang· 1 shared J Liu· 1 shared Jiejie LiuiD· 1 shared Ke LaniD· 1 shared Ming GuoiD· 1 shared Qianyun Liu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMicrobiology

Li ZhouORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJan 13, 2026

Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense

Shimin Yang, Li Zhou, Xiaoya Huang…·Yu Chen

This study identifies PABPC1 as a host factor that selectively targets viral RNA with short poly(A) tails, leading to degradation and antiviral defense, and develops a synthetic therapeutic based on this mechanism.

DOI 10.64898/2026.01.12.699136

humanbulk RNA-seq

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MicrobiologybioRxivPreprintNov 10, 2024

Generation of a biosafety mouse model infection for SARS-CoV-2 replicon delivery particles

Yingjian Li, Xiaoya Huang, Jikai Deng…·Yu Zheng Chen

The paper constructs a mouse model expressing SARS-CoV-2 N protein to study infection with SARS-CoV-2 replicon delivery particles, showing peak viral load and lung injury at 4 days post-infection.

2 citations

mousegenetic perturbation / CRISPR

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