Author

Patrick Laurette

Goethe University FrankfurtORCID 0000-0002-8941-612XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ralf GilsbachiD· 2 shared A PaascheiD· 1 shared C Cao· 1 shared Ciara Malchin· 1 shared Constanze SchmidtiD· 1 shared Deepak Prabhu RamanujamiD· 1 shared Eileen E. M. FurlongiD· 1 shared Felix WiedmanniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Ralf GilsbachORCID

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2 papers

Recent·Most cited

Transcriptional regulation of the TASK-1 potassium channel by ETV1 -Implications for atrial excitability

Moritz Beck, Felix Wiedmann, Kraft Manuel, Patrick Laurette, A Paasche, Jan D. Lanzer, Max Jamros, Ciara Malchin, Paul Henri Ziehmer, Goetz Christian, Marcin Zaradzki, Rawa Arif, Karck Matthias, Frey Norbert, Ralf Gilsbach, Constanze Schmidt

This study shows ETV1 directly regulates TASK-1 expression and contributes to atrial electrical remodelling, suggesting ETV1 as a potential therapeutic target for atrial fibrillation.

Journal of Molecular and Cellular Cardiology · Jul 30, 2026Peer-reviewedMolecular Biology

In vivo silencing of regulatory elements using a single AAV-CRISPRi vector

Patrick Laurette, C Cao, Deepak Prabhu Ramanujam, Martin Schwaderer, T. Lueneburg, S Kuss, L. Weiss, Ramile Dilshat, Eileen E. M. Furlong, Flávia Rezende, Stefan Hanns Engelhardt, Ralf Gilsbach

This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.

bioRxiv · Nov 5, 2023 · PreprintGenomics