Author

Zhen Wang

Chinese Academy of SciencesORCID 0000-0002-1695-4517Unclaimed ORCID profile · follow to get notified of new preprints

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Zhen Wang11 papers · Chinese Academy of Sciences

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Akshat SinghaliD· 1 shared Chan‐Young OckiD· 1 shared Chang Ho Ahn· 1 shared Chunhui WuiD· 1 shared Cui CheniD· 1 shared David LaubiD· 1 shared Dean BoecheriD· 1 shared Feipu YangiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Akshat SinghalORCID

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2 papers

Recent·Most cited

Translating clinical gene sequencing into a foundational representation of tumor subtype

JungHo Kong, Ingoo Lee, Dean Boecher, Akshat Singhal, Marcus R. Kelly, Jimin Moon, Chang Ho Ahn, Chan‐Young Ock, Tannavee Kumar, Timothy J. Sears, David Laub, Sarah N. Wright, Patrick Wall, Hannah K. Carter, Zhen Wang, Trey E. Ideker

This paper introduces MutationProjector, an AI model that converts tumor mutation profiles into cancer subtype representations, achieving strong performance in predicting treatment responses and classifying metastasis.

bioRxiv · Sep 8, 2025 · PreprintSystems Biology

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

Xiaoqin Tan, Xiangrui Jiang, He Yang, Feisheng Zhong, Xutong Li, Zhaoping Xiong, Zhaojun Li, Xiaohong Liu, Cui Chen, Qingjie Zhao, Yuanchao Xie, Feipu Yang, Chunhui Wu, Jingshan Shen, Mingyue Zheng, , Hualiang Jiang

This paper develops a deep learning system to design multitarget antipsychotic drugs, generating novel compounds with activity against multiple receptors and demonstrating efficacy in animal models.

European Journal of Medicinal Chemistry · Jul 11, 2020Peer-reviewedBioinformatics