Author

Sara Zirpoli

Albert Einstein College of MedicineORCID 0000-0002-8960-8463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alexander Forrest· 1 shared Antonio Di CristofanoiD· 1 shared David Mark LoebiD· 1 shared Larry H. MatherlyiD· 1 shared Noah CoppermaniD· 1 shared Shrey D. PateliD· 1 shared Zhanjun HouiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexander Forrest

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1 paper

Recent·Most cited

Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

Sara Zirpoli, Noah Copperman, Shrey D. Patel, Alexander Forrest, Zhanjun Hou, Larry H. Matherly, David Mark Loeb, Antonio Di Cristofano

This study shows that inhibiting one-carbon metabolism in Ewing sarcoma cells leads to growth suppression through purine depletion, identifying a potential therapeutic target.

bioRxiv · Apr 13, 2025 · PreprintCancer Biology