Lourdes González-Vinceiro

RNF25 Ubiquitin E3 activity Safeguards Genome Integrity by Modulating DNA Replication, Transcription and Translation.

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

miRNA-mediated cell-to-cell communications boost DNA repair during theRadioadaptative Response

The paper identifies miRNA-mediated cell-to-cell communication via extracellular vesicles that enhances DNA repair during the radioadaptive response.

PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.

PLAMseq identifies genomic loci and protein interactors in a single workflow, validated for RNA polymerase II and CTCF, and applied to study histone H1 SUMOylation.

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.