Author

Gonzalo Millán-Zambrano

Centro Andaluz de Biología Molecular y Medicina RegenerativaORCID 0000-0002-4530-6359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Laura López-HernándeziD· 3 shared Ricardo de ArellanoiD· 3 shared Emily Soto-HidalgoiD· 2 shared Iria Domínguez-García· 2 shared Luca PandolfiniiD· 2 shared Néstor García‐RodrígueziD· 2 shared Patrick Toolan-KerriD· 2 shared Román González‐PrietoiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Laura López-HernándezORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNF25 Ubiquitin E3 activity Safeguards Genome Integrity by Modulating DNA Replication, Transcription and Translation.

Emily Soto-Hidalgo, Carmen Espejo-Serrano, Ricardo de Arellano, Lourdes González-Vinceiro, María Marugán-Cardiel, Iria Domínguez-García, Ana R. Hortal, María Luisa Mateos‐Martín, Néstor García‐Rodríguez, Raimundo Freire, Gonzalo Millán-Zambrano, Román González‐Prieto

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

bioRxiv · Sep 22, 2026 · PreprintMolecular Biology

H3K37me1 couples transcription with DNA replication origin selection

Ricardo de Arellano, Patrick Toolan-Kerr, Iria Domínguez-García, Diego Polanco-Alonso, Laura López-Hernández, Simone Sidoli, Néstor García‐Rodríguez, Luca Pandolfini, Gonzalo Millán-Zambrano

This study identifies H3K37me1 as a histone modification that regulates DNA replication origin selection by limiting MCM2-7 association with transcribed chromatin.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia

Laura López-Hernández, Stephanie J. Crowley, Sara Cea-Sánchez, Ricardo de Arellano, Neetij Krishnan, Patrick Toolan-Kerr, Lynn S. White, Domenico Ignoti, Emily Soto-Hidalgo, Stefano Gustincich, Román González‐Prieto, Luca Pandolfini, Isaia Barbieri, Patricia Altea‐Manzano, Jeffrey A. Magee, , Gonzalo Millán-Zambrano

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

bioRxiv · Jan 22, 2026 · PreprintCancer Biology

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity

José Terrón-Bautista, María del Mar Martínez-Sánchez, Laura López-Hernández, Ananda Ayyappan Vadusevan, Mario García‐Domínguez, R. Scott Williams, Andrés Aguilera, Gonzalo Millán-Zambrano, Felipe Cortés‐Ledesma

The paper identifies ZATT-mediated inhibition of TOP2B as a mechanism regulating estrogen-induced transcriptional changes through DNA supercoiling.

bioRxiv · Jan 22, 2024 · PreprintMolecular Biology