Author

Lisanne Giebel

Leiden University Medical CenterORCID 0000-0002-9108-3256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alexey I. NesvizhskiiiD· 1 shared Alfred C.O. VertegaaliD· 1 shared Arnoud H. de RuiD· 1 shared Carmen Espejo-SerranoiD· 1 shared Daniel Salas‐LloretiD· 1 shared Daniela S. ThommeniD· 1 shared Diana Bocaniciu· 1 shared Emily Soto-HidalgoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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1 shared paperSystems Biology

Alexey I. NesvizhskiiORCID

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2 papers

Recent·Most cited

MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentation

Mayukha Bathini, Diana Bocaniciu, Fraser D. Johnson, Rick C.P. de Jong, Fengchao Yu, Vincenzo Davide Aloi, Marije C. Kuiken, Janniek R. Mors, Lisanne Giebel, Julien Champagne, Onno B. Bleijerveld, Reuven Agami, Krijn Kristian Dijkstra, Daniela S. Thommen, Alexey I. Nesvizhskii, Rik G.H. Lindeboom

Communications Biology · Jan 22, 2026Peer-reviewedSystems Biology

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis.

Daniel Salas‐Lloret, Néstor García‐Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos‐Martín, Arnoud H. de Ru, Peter A. van Veelen, Pablo Huertas, Alfred C.O. Vertegaal, Román González‐Prieto

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

Nature Communications · May 20, 2024Peer-reviewedMolecular Biology