Néstor García‐Rodríguez

RNF25 Ubiquitin E3 activity Safeguards Genome Integrity by Modulating DNA Replication, Transcription and Translation.

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

H3K37me1 couples transcription with DNA replication origin selection

This study identifies H3K37me1 as a histone modification that regulates DNA replication origin selection by limiting MCM2-7 association with transcribed chromatin.

miRNA-mediated cell-to-cell communications boost DNA repair during theRadioadaptative Response

The paper identifies miRNA-mediated cell-to-cell communication via extracellular vesicles that enhances DNA repair during the radioadaptive response.

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

EXO1-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.

The paper shows EXO1-mediated ssDNA gap expansion is critical for ATR activation and cell viability in BRCA1-deficient cells, revealing a therapeutic target for BRCA1-mutant cancers.