RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein
Jessica Eden, Jonathan G. G. Kaufman, Conceição Pereira, Eleanor Fox, Jérôme Cattin‐Ortolá, Lorena Benedetti, Bart Nieuwenhuis, David J. Owen, Jennifer Lippincott‐Schwartz, Sean Munro, David C. Gershlick
This study identifies RABGAP1 as a sensor that modulates APP trafficking and processing by regulating RAB activity on endosomal subdomains, with implications for Alzheimer's disease.
The EMBO Journal · Aug 26, 2025Peer-reviewedCell Biology