David J. Owen

Endocytic accessory proteins assemble clathrin while simultaneously destabilizing protein condensates

This study shows clathrin accessory proteins destabilize protein condensates while promoting clathrin lattice assembly and exclusion, revealing a mechanism linking phase separation to endocytosis.

Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks

This study shows that protein condensates and clathrin assembly regulate each other during clathrin-mediated endocytosis, enhancing vesicle formation while controlling condensate growth.

The mechanistic basis of cargo selection during Golgi maturation

This study determines the structure of the COPI vesicle coat with GOLPH3 and shows how it preferentially binds Golgi residents at late cisternae through coincidence detection of COPI and lipid.

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

This study identifies RABGAP1 as a sensor that modulates APP trafficking and processing by regulating RAB activity on endosomal subdomains, with implications for Alzheimer's disease.

Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis

This study uses biophysical methods to analyze AP2 interactions with biomimetic membranes, revealing insights into clathrin-mediated endocytosis mechanisms.

Untangling structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes

This study uses biophysical methods to show how CALM interacts with PtdIns(4,5)P2-containing membranes, revealing structural details of its membrane binding and curvature induction mechanism.

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly

The paper elucidates the structural basis of retromer core trimer assembly with SNX3, showing how it forms tubular carriers and incorporates cargo through conserved interfaces linked to Parkinson's disease mutations.

Architecture of the AP2:clathrin coat on the membranes of clathrin-coated vesicles

The paper determines the structure and interactions of AP2 and clathrin during clathrin-coated vesicle formation using cryo-EM and tomography.