Jose Luis Zugaza

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This study shows that amyloid beta oligomers induce early oligodendrocyte differentiation and dysregulated myelination in zebrafish spinal cords, with PKC as a key mediator.