Brahim Nait‐Oumesmar

Development of a Humanized Mouse Model for Studying adult Spinal Cord myelination, remyelination and Drug Efficacy

This paper develops a humanized mouse model to study human oligodendrocyte maturation, remyelination, and drug efficacy in spinal cord injury.

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth

This study shows that PSD-95 in oligodendrocytes is essential for activity-dependent myelin sheath growth through axon-oligodendrocyte connectivity in zebrafish.

Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

PAK1 and NF2/Merlin jointly drive myelination by remodeling actin cytoskeleton in oligodendrocytes

This study identifies PAK1 and NF2/Merlin as regulators of actin dynamics in oligodendrocytes, showing their role in myelin formation and expansion.

Gcm: a novel anti-inflammatory transcriptional cascade conserved from flies to humans

This study identifies a conserved anti-inflammatory transcriptional cascade involving Gcm in flies and humans, showing its role in modulating inflammation across species.

Reduced axon caliber in the associative striatum of the Sapap3 knockout mouse

The study finds reduced axon caliber in the associative striatum of Sapap3-KO mice, affecting signal conduction but not the sensorimotor striatum.