Author

Karolina A. Rygiel

University of OxfordORCID 0000-0002-9003-7880Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alison Donnelly AxtmaniD· 1 shared Andrew C. Williams· 1 shared Arunima SikdariD· 1 shared Dongxue WangiD· 1 shared Frances M. BashoreiD· 1 shared Gregory A. CaryiD· 1 shared Gregory W. CarteriD· 1 shared Haian FuiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alison Donnelly AxtmanORCID

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1 paper

Recent·Most cited

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Frances M. Bashore, Vittorio L. Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J. Bradshaw, Karolina A. Rygiel, Tina M. Leisner, Rod Chalk, Swati Mishra, Andrew C. Williams, O. Gileadi, Paul E. Brennan, Jesse C. Wiley, Jake Gockley, , Alison Donnelly Axtman

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

PLoS ONE · Feb 15, 2024Peer-reviewedNeuroscience