Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM
Frances M. Bashore, Vittorio L. Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J. Bradshaw, Karolina A. Rygiel, Tina M. Leisner, Rod Chalk, Swati Mishra, Andrew C. Williams, O. Gileadi, Paul E. Brennan, Jesse C. Wiley, Jake Gockley, , Alison Donnelly Axtman
The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.
PLoS ONE · Feb 15, 2024Peer-reviewedNeuroscience