Swati Mishra

This study shows that SORL1 deficiency in human microglia leads to lysosomal dysfunction, including impaired degradation and enzyme activity, contributing to Alzheimer's disease pathogenesis.

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

The paper tests if a retromer stabilizing drug, TPT-260, can correct endosomal and Alzheimer's-related pathologies in neurons with SORL1 variants.

The paper introduces a computational framework integrating genomic, transcriptomic, and proteomic data to identify and interpret translated fusions and micro structural variations in cancer, finding many novel peptides and private aberrations in breast cancer.